Laptop recomendation for bioinformatics


TLDR

Qualities of a good bioinformatics laptop

  1. Linux compatible
  2. Cheap
  3. Easy to carry around
  4. Powerful enough to open a web browser and a text editor

What you will use the laptop for

  1. editing text files
  2. connecting to a server via ssh
  3. running scripts on a server
  4. writing papers and creating presentations
  5. browsing internet

What you won't use the laptop for

  1. training ML models
  2. running actuall analysis pipelines
  3. basically anything computationally demanding

As a rule of thumb almost anything that higher spec consumer grade hardware can do, can be done almost as well on much cheaper hardware.

Realistically if you really can't do something on a budget laptop, you need to start looking for an HPC. Which should be provided by your PI/employer.

In my opinion you should treat your laptop as a portable terminal and prioritize comfort over hardware specification. When I was searching for my current laptop I cared more about whether it had a HDMI and ETHERNET ports and comfortable keyboard, than exact CPU specs or size of RAM.

There are obvious downsides to using older hardware. You're essentially forced to use Linux, because Windows will be laggy or refuse to install. You will need to be more conservative with resources, eg. no more than 64 firefox tabs open, which might feel like very little during active literature reviews. Software that you are forced to use might be a pain (Microsoft Teams is really resource hungry for some reason).

The gist is that if you're willing to be slightly more minimalist in your computing you can get a high build quality very capable laptop for less than 500$ or even 200$.

Gallery

Lenovo Thinkpad X220
2011 Lenovo Thinkpad X220 was what I started with in 2023. Cost me 60$ + 40$ for a new battery.
Lenovo Thinkpad T14 3rd gen
2022 Lenovo Thinkpad T14 3rd Gen I bought for equiv. of 590$